Cardiac Fibrosis

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Cardiac Fibrosis

Heart failure, the clinical manifestation of numerous forms of cardiovascular disease, is a devastating disorder characterized by interstitial fibrosis, chamber remodeling, and reduced ventricular compliance. Heart disease remains the predominant cause of mortality in the United States, accounting for nearly 800 000 deaths per year. Furthermore, it presents a considerable economic burden, with ...

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Chemokines and cardiac fibrosis.

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Macrophage-mediated cardiac fibrosis.

Both clinicians and investigators have long tended to consider cardiac fibrosis as a hopelessly unavoidable “final common pathway” of tissue injury. We are painfully familiar with the serious consequences of myocardial fibrosis, including diastolic dysfunction and promoting reentry dysrhythmias,1 but we seem to accept that diseased myocardium eventually develops fibrosis. However, only the most...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 2016

ISSN: 0009-7330,1524-4571

DOI: 10.1161/circresaha.115.306565